Cell Senescence Entries for PRKD1
- Cell Types
- Lung fibroblast
- Cell Lines
- IMR-90
- Cancer Cell?
- No
- Method
- Knockdown, Overexpression
- Type of senescence
- Oncogene-induced
- Senescence Effect
- Induces
- Primary Reference
- Wang et al. (2014) Protein kinase D1 is essential for Ras-induced senescence and tumor suppression by regulating senescence-associated inflammation. Proc Natl Acad Sci U S A 111(21)7683-8 (PubMed)
PRKD1 Gene Information
- HGNC symbol
- PRKD1
- Aliases
- PKC-mu; PKCM; PKD; PRKCM
- Common name
- protein kinase D1
- Entrez Id
- 5587
- Description
- The protein encoded by this gene is a serine/threonine protein kinase involved in many cellular processes, including Golgi body membrane integrity and transport, cell migration and differentiation, MAPK8/JNK1 and Ras pathway signaling, MAPK1/3 (ERK1/2) pathway signaling, cell survival, and regulation of cell shape and adhesion. [provided by RefSeq, Jan 2017].
PRKD1 Ontologies
- Gene Ontology
-
Process: GO:6468; protein phosphorylation
GO:16310; phosphorylation
GO:6915; apoptotic process
GO:43123; positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:30154; cell differentiation
GO:2376; immune system process
GO:45087; innate immune response
GO:7399; nervous system development
GO:18105; peptidyl-serine phosphorylation
GO:6954; inflammatory response
GO:1525; angiogenesis
And 39 more GO terms Cellular component: GO:5737; cytoplasm
GO:16020; membrane
GO:5794; Golgi apparatus
GO:5829; cytosol
GO:5886; plasma membrane
GO:5802; trans-Golgi network
GO:421; autophagosome membrane
GO:5634; nucleus
GO:5911; cell-cell junction
GO:5938; cell cortex
Show all GO termsFunction: GO:46872; metal ion binding
GO:166; nucleotide binding
GO:4672; protein kinase activity
GO:4674; protein serine/threonine kinase activity
GO:4712; protein serine/threonine/tyrosine kinase activity
GO:5524; ATP binding
GO:16301; kinase activity
GO:16740; transferase activity
GO:106310; protein serine kinase activity
GO:5515; protein binding
GO:4697; protein kinase C activity
And 3 more GO terms
Homologs of PRKD1 in Model Organisms
- Caenorhabditis elegans
- dkf-1
- Caenorhabditis elegans
- dkf-2
- Danio rerio
- prkd1
- Drosophila melanogaster
- PKD
- Mus musculus
- Prkd1
- Rattus norvegicus
- Prkd1
In other databases
- GenAge model organism genes
- A homolog of this gene for Caenorhabditis elegans is present as dkf-2
External links
- OMIM
- 605435
- Ensembl
- ENSG00000184304
- Entrez Gene
- 5587
- UniGene
- 508999
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- PRKD1
- GeneCards
- PRKD1