Cell Senescence Entries for PINK1

Cell Types

Nucleus pulposus

Cell Lines

Primary cell

Cancer Cell?

No

Method

Knockdown

Type of senescence

Stress-induced

Senescence Effect

Inhibits

Primary Reference

Wang et al. (2019) PINK1 protects against oxidative stress induced senescence of human nucleus pulposus cells via regulating mitophagy. Biochem Biophys Res Commun 504(2)406-414 (PubMed)

PINK1 Gene Information

HGNC symbol

PINK1 

Aliases

BRPK; PARK6 

Common name

PTEN induced kinase 1 

Entrez Id

65018

Description

This gene encodes a serine/threonine protein kinase that localizes to mitochondria. It is thought to protect cells from stress-induced mitochondrial dysfunction. Mutations in this gene cause one form of autosomal recessive early-onset Parkinson disease. [provided by RefSeq, Jul 2008].

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PINK1 Ontologies

Gene Ontology

Process:

GO:6468; protein phosphorylation GO:16310; phosphorylation GO:16567; protein ubiquitination GO:6914; autophagy GO:35556; intracellular signal transduction GO:50821; protein stabilization GO:422; autophagy of mitochondrion GO:42981; regulation of apoptotic process GO:31396; regulation of protein ubiquitination GO:1903146; regulation of autophagy of mitochondrion GO:1903214; regulation of protein targeting to mitochondrion

And 70 more GO terms

Cellular component:	GO:5737; cytoplasm GO:16020; membrane GO:16021; integral component of membrane GO:5783; endoplasmic reticulum GO:5739; mitochondrion GO:5743; mitochondrial inner membrane GO:5741; mitochondrial outer membrane GO:5829; cytosol GO:5634; nucleus GO:48471; perinuclear region of cytoplasm GO:785; chromatin
	And 9 more GO terms

Function:	GO:46872; metal ion binding GO:166; nucleotide binding GO:4672; protein kinase activity GO:4674; protein serine/threonine kinase activity GO:4712; protein serine/threonine/tyrosine kinase activity GO:5524; ATP binding GO:16301; kinase activity GO:16740; transferase activity GO:106310; protein serine kinase activity GO:31625; ubiquitin protein ligase binding GO:5515; protein binding
	And 9 more GO terms

Show all GO terms

Homologs of PINK1 in Model Organisms

Caenorhabditis elegans

pink-1

Danio rerio

pink1

Drosophila melanogaster

Pink1

Mus musculus

Pink1

Rattus norvegicus

Pink1

In other databases

GenAge model organism genes

• A homolog of this gene for Drosophila melanogaster is present as Pink1

CellAge gene expression

• This gene is present as PINK1

External links

OMIM

608309

Ensembl

ENSG00000158828

Entrez Gene

65018

UniGene

389171

1000 Genomes

1000 Genomes

HPRD

GenAtlas

PINK1

GeneCards

PINK1