Cell Senescence Entries for NRAS

Cell Types

Foreskin melanocyte

Cell Lines

Primary cell

Cancer Cell?

No

Method

Mutation, Overexpression

Type of senescence

Oncogene-induced

Senescence Effect

Induces

Primary Reference

Denoyelle et al. (2006) Anti-oncogenic role of the endoplasmic reticulum differentially activated by mutations in the MAPK pathway. Nat Cell Biol 8(10)1053-63 (PubMed)

NRAS Gene Information

HGNC symbol

NRAS 

Aliases

N-ras 

Common name

NRAS proto-oncogene, GTPase 

Entrez Id

4893

Description

This is an N-ras oncogene encoding a membrane protein that shuttles between the Golgi apparatus and the plasma membrane. This shuttling is regulated through palmitoylation and depalmitoylation by the ZDHHC9-GOLGA7 complex. The encoded protein, which has intrinsic GTPase activity, is activated by a guanine nucleotide-exchange factor and inactivated by a GTPase activating protein. Mutations in this gene have been associated with somatic rectal cancer, follicular thyroid cancer, autoimmune lymphoproliferative syndrome, Noonan syndrome, and juvenile myelomonocytic leukemia. [provided by RefSeq, Jun 2011].

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NRAS Ontologies

Gene Ontology

Process:

GO:7165; signal transduction GO:7265; Ras protein signal transduction GO:1938; positive regulation of endothelial cell proliferation GO:165; MAPK cascade

Cellular component:

GO:16020; membrane GO:5794; Golgi apparatus GO:5886; plasma membrane GO:139; Golgi membrane GO:5789; endoplasmic reticulum membrane GO:5829; cytosol GO:70062; extracellular exosome GO:70821; tertiary granule membrane

Function:

GO:166; nucleotide binding GO:16787; hydrolase activity GO:3924; GTPase activity GO:5525; GTP binding GO:3925; G protein activity GO:5515; protein binding GO:44877; protein-containing complex binding GO:19003; GDP binding

Show all GO terms

Homologs of NRAS in Model Organisms

Caenorhabditis elegans

let-60

Danio rerio

nras

Drosophila melanogaster

Ras85D

Mus musculus

Nras

Rattus norvegicus

Nras

Saccharomyces cerevisiae

RAS2

Saccharomyces cerevisiae

RAS1

In other databases

GenAge model organism genes

• A homolog of this gene for Caenorhabditis elegans is present as let-60
• A homolog of this gene for Saccharomyces cerevisiae is present as RAS1
• A homolog of this gene for Saccharomyces cerevisiae is present as RAS2

CellAge gene expression

• This gene is present as NRAS

External links

OMIM

164790

Ensembl

ENSG00000213281

Entrez Gene

4893

UniGene

486502

1000 Genomes

1000 Genomes

HPRD

GenAtlas

NRAS

GeneCards

NRAS