The GNG11 gene and its putative association with human ageing

Cell Senescence Entries for GNG11

Cell Types: Lung fibroblast
Cell Lines: TIG-7
Cancer Cell?: No
Method: Knockout, Overexpression
Type of senescence: Stress-induced
Senescence Effect: Induces
Primary Reference: Hossain et al. (2007) G-protein gamma subunit GNG11 strongly regulates cellular senescence. Biochem Biophys Res Commun 351(3)645-50 (PubMed)

HGNC symbol: GNG11
Aliases: GNGT11
Common name: G protein subunit gamma 11
Entrez Id: 2791
Description: This gene is a member of the guanine nucleotide-binding protein (G protein) gamma family and encodes a lipid-anchored, cell membrane protein. As a member of the heterotrimeric G protein complex, this protein plays a role in this transmembrane signaling system. This protein is also subject to carboxyl-terminal processing. Decreased expression of this gene is associated with splenic marginal zone lymphomas. [provided by RefSeq, Jul 2008].

Gene Ontology

Process:

GO:7186; G protein-coupled receptor signaling pathway
GO:7165; signal transduction

Cellular component:

GO:16020; membrane
GO:5886; plasma membrane
GO:5834; heterotrimeric G-protein complex

Function:

GO:5515; protein binding
GO:31681; G-protein beta-subunit binding
GO:3924; GTPase activity

Show all GO terms