Cell Senescence Entries for DGCR8
- Cell Types
- Lung fibroblast
- Cell Lines
- IMR-90
- Cancer Cell?
- No
- Method
- Knockdown
- Type of senescence
- Unclear
- Senescence Effect
- Inhibits
- Primary Reference
- Gómez-Cabello et al. (2014) DGCR8-mediated disruption of miRNA biogenesis induces cellular senescence in primary fibroblasts. Aging Cell 12(5)923-31 (PubMed)
DGCR8 Gene Information
- HGNC symbol
- DGCR8
- Aliases
- C22orf12; DGCRK6; Gy1; pasha
- Common name
- DGCR8 microprocessor complex subunit
- Entrez Id
- 54487
- Description
- This gene encodes a subunit of the microprocessor complex which mediates the biogenesis of microRNAs from the primary microRNA transcript. The encoded protein is a double-stranded RNA binding protein that functions as the non-catalytic subunit of the microprocessor complex. This protein is required for binding the double-stranded RNA substrate and facilitates cleavage of the RNA by the ribonuclease III protein, Drosha. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010].
DGCR8 Ontologies
- Gene Ontology
-
Process: GO:31053; primary miRNA processing
Cellular component: GO:5634; nucleus
GO:5654; nucleoplasm
GO:5829; cytosol
GO:16604; nuclear body
GO:5730; nucleolus
GO:5737; cytoplasm
GO:70877; microprocessor complex
Show all GO termsFunction: GO:3723; RNA binding
GO:46872; metal ion binding
GO:5515; protein binding
GO:20037; heme binding
GO:42802; identical protein binding
GO:42803; protein homodimerization activity
GO:3725; double-stranded RNA binding
GO:70878; primary miRNA binding
GO:140517; protein-RNA adaptor activity
Homologs of DGCR8 in Model Organisms
- Caenorhabditis elegans
- pash-1
- Danio rerio
- dgcr8
- Drosophila melanogaster
- pasha
- Mus musculus
- Dgcr8
- Rattus norvegicus
- Dgcr8
In other databases
- GenAge model organism genes
- A homolog of this gene for Caenorhabditis elegans is present as pash-1
External links
- OMIM
- 609030
- Ensembl
- ENSG00000128191
- Entrez Gene
- 54487
- UniGene
- 713579
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- DGCR8
- GeneCards
- DGCR8