December 23, 2020
Build 2 of CellAge is now available online. In addition to the 279 genes associated with cell senescence based on genetic manipulation experiments, this new build a gene expression signature of cellular senescence consisting of 1,259 genes, as detailed in the release notes.Number of genes inferred from genetic manipulations:
Number of genes from expression changes:
February 9, 2020
July 9, 2019
We have released build 3 of DrugAge. This build represents a major improvement as we fixed several small errors in the data and added hundreds of new entries. We also updated the interface. The build 3 of DrugAge features 1,821 entries from 567 drugs, as detailed in the release notes.
October 14, 2017
Build 14 of AnAge has been released. This build is primarily a qualitative improvement. Only a few new species were added, but dozens of entries were updated and ~150 references were added. For more details, please consult the release notes.
September 13, 2017
We will be holding a two-day workshop and meeting on October 26-27, 2017, focused on ageing and the application of bioinformatic and genomic technologies to the study of ageing and longevity. For more information and to register/abstract submission please see our 2017 ageing meeting.
June 24, 2017
November 13, 2016
September 21, 2016
We have released a new database of genes associated with cell senescence, which we have called CellAge. Featuring 144 entries, CellAge is still in the beta phase of development and therefore undergoing testing and still being improved and expanded.
September 1, 2016
We have released build 2 of DrugAge. This build represents a significant improvement as we fixed several small errors in the data and added dozens of new entries. The build 2 of DrugAge features 1,316 entries from 418 drugs, as detailed in the release notes.
February 24, 2016
DrugAge, a new database of ageing-related drugs, has been released. Over 1,000 entries of drugs, compounds and supplements that extend longevity in model organisms are featured. As such, DrugAge is the most comprehensive compilation of anti-ageing drugs and compounds available online.
February 14, 2016
We have released build 2 of the LongevityMap. This build is a significant update with dozens of new studies and hundreds of new variants included. The new LongevityMap build features 551 manually-curated entries, 860 genes and 3,025 genetic variants, as detailed in the release notes.
October 11, 2015
Build 18 of GenAge was released. This build is a significant update with over 200 genes added. The new GenAge build features 305 manually-curated human genes and 2,054 genes in model organisms, as detailed in the release notes.
September 17, 2015
Build 3 of GenDR was released. This build is a significant update with many genes added, including some new mouse genes. The new GenDR build features 172 genes inferred from genetic manipulation experiments, as described in the release notes.
January 6, 2015
We have released the Bowhead Whale Genome Resource, a web portal that aims to assist researchers interested in the genome and genes of the bowhead whale (Balaena mysticetus), the longest-lived mammal. This portal includes a high-coverage genome assembly and features mappings of bowhead genes to orthologs in other species, molecular evolution rates (i.e., Ka/Ks), alignments, etc.
April 18, 2014
We have released the Naked Mole-Rat Genome Resource, a web portal that aims to assist researchers interested in the genome and genes of the long-lived, cancer-resistant naked mole rat (Heterocephalus glaber). This portal includes a high-quality genome assembly and features mappings of naked mole rat genes to orthologs in other species, molecular evolution rates (i.e., Ka/Ks), alignments, etc.
February 10, 2014
We have released a new database called LibAge, the bibliographical library of ageing. References from our gene-centric databases (i.e., GenAge, GenDR and LongevityMap) now link to LibAge which thus provides a centralized repository for HAGR's bibliography. Please note, however, that LibAge is still considered a beta version, undergoing testing and with several plans for improvements.
January 13, 2014
AnAge build 13 was released. This build is primarily a qualitative improvement. Only a few new species were added, but dozens of entries were updated and new references added. For more details, please consult the release notes.
December 18, 2013
Build 17 of GenAge and build 2 of GenDR were released. These builds are major updates in both quantity and quality of data with hundreds of genes added or updated and hundreds of new references added. The new GenAge build features 298 manually-curated human genes and 1,825 genes in model organisms, as detailed in the release notes. The new GenDR build features 149 genes inferred from genetic manipulation experiments, as described in the release notes.
June 26, 2013
The LongevityMap, a database of human genetic variants associated with longevity, has been released. Over 2,000 genes and variants previously studied in context of longevity are featured. As such, the LongevityMap serves as a repository of genetic association studies of longevity and reflects our current knowledge of the genetics of human longevity.
January 2, 2013
A new description of HAGR detailing its latest updates and novel features has been published in Nucleic Acids Research (41(D1):D1027–D1033). This more recent description of HAGR becomes the official citation of HAGR.
September 18, 2012
GenAge build 16 and AnAge build 12 were released. Both these builds are major updates in both quantity and quality of data. The new GenAge build features 288 manually-curated human genes and 1,712 genes in model organisms, as detailed in the release notes. The new AnAge build features 4,230 entries and hundreds of updated longevity records and entries, as described in the release notes.
July 18, 2012
The first database of genes associated with dietary restriction (DR), entitled GenDR, has been released to facilitate research on the genetic and molecular mechanisms of DR-induced life-extension. GenDR includes two datasets, each with ~150 genes: 1) genes inferred from experiments in model organisms in which genetic manipulations cancel out or disrupt the life-extending effects of DR; 2) genes robustly altered due to DR, derived from a meta-analysis of microarray DR studies in mammals.
June 6, 2012
An improved interface for HAGR was unveiled. The new version will aid in the navigation and browsing of our different resources. URLs and tools remain largely the same so, while the interface should be more intuitive, the functionality of our resources has not changed.
September 19, 2010
The molecular signatures of ageing identified by our group in 2009 through a meta-analysis of ageing microarray experiments in mammals have been incorporated into a searchable database. In addition, numerous changes have been made to HAGR's main page and user interface, updating and enhancing several aspects to improve functionality.
March 17, 2010
GenAge build 15 was released. This latest build is mostly a data update and features 261 manually-curated human genes and 789 genes in model organisms. Further details are available in the release notes.
August 13, 2009
A new description of AnAge has been published in the Journal of Evolutionary Biology (22(8):1770-1774). This work details aspects of data collection, organization and quality assessment as well as some new features in AnAge and its potential uses in a broad range of biological disciplines.
May 7, 2009
AnAge build 11 was released. This build is a qualitative improvement. No new species were added, but several improvements were made to existing entries. For more details, please consult the release notes.
April 30, 2009
By combining ageing gene expression profiles from different tissues in mice, rats and humans, conserved molecular signatures of ageing were derived. These signatures reveal genes and processes consistently over- or underexpressed with age including previously unknown transcriptional changes with age. Further details as well as the full results are available online.
February 16, 2009
An updated description of HAGR and of its uses has been published in Aging Cell (8(1):65-72). This more recent description of HAGR details numerous enhancements and becomes the official citation of HAGR or of any of its resources.
July 20, 2008
GenAge build 14 was released. This latest build features 261 manually-curated human genes, 789 genes in model organisms, and an updated bibliography. Further details are available in the release notes.
April 18, 2008
AnAge build 10 was released, featuring 4,122 entries. In addition to numerous updates and additions, this build features vastly improved data for birds. For more details, please consult the release notes.
December 17, 2007
Through demographic parameters, namely the slope of the mortality curve, it is possible to estimate the rate of ageing of a given population, which can be useful to compare the rate of ageing between species or between animal cohorts used in experiments. A method to obtain such estimates of the ageing rate, as well as an SPSS script to aid in the calculations, is now described in the software section.
June 20, 2007
An extensive list of genes analyzed for their possible association with human longevity has been included in GenAge. While genes associated with human longevity have been featured before in GenAge, this latest dataset with over 200 genes tested for their possible association with human longevity and/or survival in old age represents a major update.
February 7, 2007
In addition to GenAge's putative human ageing-related genes, GenAge now features genes related to longevity and/or ageing in model organisms. In build 13 released today, 411 genes from model organisms are included. This expansion of GenAge was done in collaboration with Vadim Fraifeld who is now a curator for GenAge. Further details about build 13 are available in the release notes.
06.01.2015 - Scientists sequence genome of longest-lived mammal (University of Liverpool press release)
05.09.2014 - Naked mole rat genome helps cancer resistance research (The Genome Analysis Centre press release)
29.03.2012 - Study suggests why some animals live longer (University of Liverpool press release)
04.11.2011 - Scientists identify genes that may signal long life in naked mole-rats (University of Liverpool press release)
06.07.2011 - Scientists sequence DNA of cancer-resistant rodent (University of Liverpool press release)
24.04.2009 - Study identifies genes that protect against ageing (University of Liverpool press release)
17.02.2009 - Scientists develop resource to study animal ageing (University of Liverpool press release)
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