LongevityMap Gene
Gene details
- HGNC symbol
- ZWINT
- Aliases
- SIP30; ZWINT1; KNTC2AP; HZwint-1
- Common name
- ZW10 interacting kinetochore protein
- Description
- This gene encodes a protein that is clearly involved in kinetochore function although an exact role is not known. It interacts with ZW10, another kinetochore protein, possibly regulating the association between ZW10 and kinetochores. The encoded protein localizes to prophase kinetochores before ZW10 does and it remains detectable on the kinetochore until late anaphase. It has a uniform distribution in the cytoplasm of interphase cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
- Cytogenetic Location
- 10q21.1
- UCSC Genome Browser
- View 10q21.1 on the UCSC genome browser
- OMIM
- 609177
- Ensembl
- ENSG00000122952
- UniProt/Swiss-Prot
- ZWINT_HUMAN
- Entrez Gene
- 11130
- UniGene
- 591363
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
In other databases
- CellAge gene expression
- This gene is present as ZWINT
Studies (1)
Significant/Non-significant: 1/0
- Longevity Association
- Significant
- Population
- American (Caucasian)
- Study Design
- Genome-wide association study in 801 centenarians and 914 healthy controls
- Conclusions
- 281 SNPs were found to discriminate between cases and controls
- Indentifier
- rs11005328
- Reference