LongevityMap Gene
Gene details
- HGNC symbol
- ZW10
- Aliases
- HZW10; KNTC1AP
- Common name
- zw10 kinetochore protein
- Description
- This gene encodes a protein that is one of many involved in mechanisms to ensure proper chromosome segregation during cell division. This protein is an essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. [provided by RefSeq, Aug 2011]
- Cytogenetic Location
- 11q23.2
- UCSC Genome Browser
- View 11q23.2 on the UCSC genome browser
- OMIM
- 603954
- Ensembl
- ENSG00000086827
- UniProt/Swiss-Prot
- ZW10_HUMAN
- Entrez Gene
- 9183
- UniGene
- 503886
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
- Caenorhabditis elegans
- czw-1
- Danio rerio
- zw10
- Drosophila melanogaster
- Zw10
- Mus musculus
- Zw10
- Rattus norvegicus
- Zw10
In other databases
- CellAge gene expression
- This gene is present as ZW10
Studies (1)
Significant/Non-significant: 0/1
- Longevity Association
- Non-significant
- Population
- Caucasians
- Study Design
- Meta-analysis of GWAS in Caucasians from four prospective cohort studies: the Age, Gene/Environment Susceptibility-Reykjavik Study, the Cardiovascular Health Study, the Framingham Heart Study, and the Rotterdam Study participating in the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium. Longevity was defined as survival to age 90 years or older (n = 1,836); the comparison group comprised cohort members who died between the ages of 55 and 80 years (n = 1,955).
- Conclusions
- There were 273 single-nucleotide polymorphism (SNP) associations with p < .0001, but none reached significance after correcting for multiple testing
- Indentifier
- rs17541000
- Reference