LongevityMap Gene
Gene details
- HGNC symbol
- YBX1
- Aliases
- YB1; BP-8; CSDB; DBPB; YB-1; CBF-A; CSDA2; EFI-A; NSEP1; NSEP-1; MDR-NF1
- Common name
- Y-box binding protein 1
- Description
- This gene encodes a highly conserved cold shock domain protein that has broad nucleic acid binding properties. The encoded protein functions as both a DNA and RNA binding protein and has been implicated in numerous cellular processes including regulation of transcription and translation, pre-mRNA splicing, DNA reparation and mRNA packaging. This protein is also a component of messenger ribonucleoprotein (mRNP) complexes and may have a role in microRNA processing. This protein can be secreted through non-classical pathways and functions as an extracellular mitogen. Aberrant expression of the gene is associated with cancer proliferation in numerous tissues. This gene may be a prognostic marker for poor outcome and drug resistance in certain cancers. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on multiple chromosomes. [provided by RefSeq, Sep 2015]
- Cytogenetic Location
- 1p34.2
- UCSC Genome Browser
- View 1p34.2 on the UCSC genome browser
- OMIM
- 154030
- Ensembl
- ENSG00000065978
- UniProt/Swiss-Prot
- YBOX1_HUMAN
- Entrez Gene
- 4904
- UniGene
- 473583
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
- Caenorhabditis elegans
- cey-1
- Caenorhabditis elegans
- cey-4
- Caenorhabditis elegans
- cey-3
- Caenorhabditis elegans
- cey-2
- Danio rerio
- ybx1
- Drosophila melanogaster
- yps
- Mus musculus
- Ybx1
- Rattus norvegicus
- LOC100912427
- Rattus norvegicus
- Ybx1
In other databases
- CellAge
- This gene is present as YBX1
Studies (1)
Significant/Non-significant: 0/1
- Longevity Association
- Non-significant
- Population
- Danish
- Study Design
- 592 SNPs from 77 genes involved in nine sub-processes were analyzed in 1089 long-lived and 736 middle-aged Danes. Then, a replicated study was carried out in a German cohort.
- Conclusions
- The results did not remain significant after correction. The findings drawn from the Danish cohort were not replicated in German samples.
- Indentifier
- rs11210696
- Reference