LongevityMap Gene
Gene details
- HGNC symbol
- XDH
- Aliases
- XO; XOR; XAN1
- Common name
- xanthine dehydrogenase
- Description
- Xanthine dehydrogenase belongs to the group of molybdenum-containing hydroxylases involved in the oxidative metabolism of purines. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Xanthine dehydrogenase can be converted to xanthine oxidase by reversible sulfhydryl oxidation or by irreversible proteolytic modification. Defects in xanthine dehydrogenase cause xanthinuria, may contribute to adult respiratory stress syndrome, and may potentiate influenza infection through an oxygen metabolite-dependent mechanism. [provided by RefSeq, Jan 2014]
- Cytogenetic Location
- 2p23.1
- UCSC Genome Browser
- View 2p23.1 on the UCSC genome browser
- OMIM
- 607633
- Ensembl
- ENSG00000158125
- UniProt/Swiss-Prot
- XDH_HUMAN
- Entrez Gene
- 7498
- UniGene
- 250
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
- Caenorhabditis elegans
- F55B11.1
- Caenorhabditis elegans
- gad-3
- Caenorhabditis elegans
- F15E6.6
- Danio rerio
- xdh
- Drosophila melanogaster
- AOX4
- Drosophila melanogaster
- ry
- Drosophila melanogaster
- AOX1
- Drosophila melanogaster
- AOX2
- Drosophila melanogaster
- AOX3
- Mus musculus
- Xdh
- Rattus norvegicus
- Xdh
In other databases
- GenAge model organism genes
Studies (3)
Significant/Non-significant: 2/1
Study 1
- Longevity Association
- Significant
- Population
- Danish
- Study Design
- Alleles in candidate pathways (GH/IGF1 signaling, DNA damage signaling and repair and pro/antioxidants) were investigated for association with longevity in 1089 oldest-old (age 92-93) and 736 middle-aged Danes
- Conclusions
- Six SNPs (in TNXRD1, XDH, GHRL, MLH1, H2AFX, XRCC5) were associated with mortality in late life after correction for multiple hypothesis testing. No replications were observed in German and Dutch populations.
- Indentifier
- rs207444
- Reference
Study 2
- Longevity Association
- Significant
- Population
- American (Caucasian)
- Study Design
- Genome-wide association study in 801 centenarians and 914 healthy controls
- Conclusions
- 281 SNPs were found to discriminate between cases and controls
- Indentifier
- rs4952085
- Reference
Study 3
- Longevity Association
- Non-significant
- Population
- Danish
- Study Design
- 38 genes (311 SNPs) belonging to pro-antioxidant pathways were investigated for the association with physical and cognitive performances in a Cohort of 1089 Danish nonagenarians. For each gene analyzed in the pro-antioxidant pathway, the influence on longitudinal survival was tested.
- Conclusions
- No gene found associated with a functional phenotype showed a corresponding association with survival in the whole cohort. NDUFS1, TXNRD1, SOD2 and UCP3 were found significantly associated with lifespan in the female cohort. No association with survival was reported in males for genes belonging to the pro-oxidant pathway here analyzed.
- Indentifier
- rs1042039
- Reference