LongevityMap Gene

Gene details

HGNC symbol: WWOX
Aliases: FOR; WOX1; EIEE28; FRA16D; SCAR12; HHCMA56; PRO0128; SDR41C1; D16S432E
Common name: WW domain containing oxidoreductase
Description: This gene encodes a member of the short-chain dehydrogenases/reductases (SDR) protein family. This gene spans the FRA16D common chromosomal fragile site and appears to function as a tumor suppressor gene. Expression of the encoded protein is able to induce apoptosis, while defects in this gene are associated with multiple types of cancer. Disruption of this gene is also associated with autosomal recessive spinocerebellar ataxia 12. Disruption of a similar gene in mouse results in impaired steroidogenesis, additionally suggesting a metabolic function for the protein. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
Cytogenetic Location: 16q23.1-q23.2
UCSC Genome Browser: View 16q23.1-q23.2 on the UCSC genome browser
OMIM: 605131
Ensembl: ENSG00000186153
UniProt/Swiss-Prot: WWOX_HUMAN
Entrez Gene: 51741
UniGene: 461453
1000 Genomes: 1000 Genomes

Significant/Non-significant: 1/0

Longevity Association

Significant

Population

American (Caucasian)

Study Design

Genome-wide association study in 801 centenarians and 914 healthy controls

Conclusions

281 SNPs were found to discriminate between cases and controls

Indentifier

rs2738679

Reference