LongevityMap Gene
Gene details
- HGNC symbol
- UNG
- Aliases
- DGU; UDG; UNG1; UNG2; HIGM4; HIGM5; UNG15
- Common name
- uracil DNA glycosylase
- Description
- This gene encodes one of several uracil-DNA glycosylases. One important function of uracil-DNA glycosylases is to prevent mutagenesis by eliminating uracil from DNA molecules by cleaving the N-glycosylic bond and initiating the base-excision repair (BER) pathway. Uracil bases occur from cytosine deamination or misincorporation of dUMP residues. Alternative promoter usage and splicing of this gene leads to two different isoforms: the mitochondrial UNG1 and the nuclear UNG2. The UNG2 term was used as a previous symbol for the CCNO gene (GeneID 10309), which has been confused with this gene, in the literature and some databases. [provided by RefSeq, Nov 2010]
- Cytogenetic Location
- 12q24.11
- UCSC Genome Browser
- View 12q24.11 on the UCSC genome browser
- OMIM
- 191525
- Ensembl
- ENSG00000076248
- UniProt/Swiss-Prot
- E5KTA5_HUMAN
- Entrez Gene
- 7374
- UniGene
- 191334
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
- Caenorhabditis elegans
- ung-1
- Danio rerio
- unga
- Mus musculus
- Ung
- Rattus norvegicus
- Ung
- Saccharomyces cerevisiae
- UNG1
- Schizosaccharomyces pombe
- ung1
Studies (1)
Significant/Non-significant: 0/1
- Longevity Association
- Non-significant
- Population
- Danish
- Study Design
- 592 SNPs from 77 genes involved in nine sub-processes were analyzed in 1089 long-lived and 736 middle-aged Danes. Then, a replicated study was carried out in a German cohort.
- Conclusions
- The results did not remain significant after correction. The findings drawn from the Danish cohort were not replicated in German samples.
- Indentifier
- rs2569987
- Reference