LongevityMap Gene
Gene details
- HGNC symbol
- UCK2
- Aliases
- UK; UMPK; TSA903
- Common name
- uridine-cytidine kinase 2
- Description
- This gene encodes a pyrimidine ribonucleoside kinase. The encoded protein (EC 2.7.1.48) catalyzes phosphorylation of uridine and cytidine to uridine monophosphate (UMP) and cytidine monophosphate (CMP), respectively.[provided by RefSeq, Oct 2010]
- Cytogenetic Location
- 1q24.1
- UCSC Genome Browser
- View 1q24.1 on the UCSC genome browser
- OMIM
- 609329
- Ensembl
- ENSG00000143179
- UniProt/Swiss-Prot
- A0A024R912_HUMAN
- Entrez Gene
- 7371
- UniGene
- 458360
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
- Caenorhabditis elegans
- B0001.4
- Danio rerio
- uck2b
- Danio rerio
- uck2a
- Drosophila melanogaster
- CG6364
- Mus musculus
- Uck2
- Rattus norvegicus
- Uck2
- Saccharomyces cerevisiae
- URK1
Studies (1)
Significant/Non-significant: 0/1
- Longevity Association
- Non-significant
- Population
- American, English, Irish
- Study Design
- 10 late-onset Alzheimer's disease genes were tested for association with human aging in the dataset (1385 samples with documented age at death, age range: 58–108 years; mean age at death: 80.2 years) using the most significant SNPs found in the previous studies. A set of 41 tentative SNPs span the genome were identified in this study.
- Conclusions
- Some signals were at best tentative but may merit study in larger sample sets
- Indentifier
- rs12562047
- Reference