LongevityMap Gene

Gene details

HGNC symbol: UBE2H
Aliases: GID3; UBC8; UBCH; UBCH2; E2-20K
Common name: ubiquitin conjugating enzyme E2 H
Description: The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein sequence is 100% identical to the mouse homolog and 98% identical to the frog and zebrafish homologs. Three alternatively spliced transcript variants have been found for this gene and they encode distinct isoforms. [provided by RefSeq, Feb 2011]
Cytogenetic Location: 7q32.2
UCSC Genome Browser: View 7q32.2 on the UCSC genome browser
OMIM: 601082
Ensembl: ENSG00000186591
UniProt/Swiss-Prot: A4D1L5_HUMAN
Entrez Gene: 7328
UniGene: 643548
1000 Genomes: 1000 Genomes

Homologs in model organisms

Caenorhabditis elegans: ubc-8
Danio rerio: ube2h
Drosophila melanogaster: UbcE2H
Mus musculus: Ube2h
Rattus norvegicus: Ube2h
Saccharomyces cerevisiae: UBC8
Schizosaccharomyces pombe: ubc8

In other databases

GenAge model organism genes

A homolog of this gene for Saccharomyces cerevisiae is present as UBC8

CellAge gene expression

This gene is present as UBE2H

Studies (1)

Significant/Non-significant: 1/0

Longevity Association

Significant

Population

American (Caucasian)

Study Design

Genome-wide association study in 801 centenarians and 914 healthy controls

Conclusions

281 SNPs were found to discriminate between cases and controls

Indentifier

Reference