LongevityMap Gene
Gene details
- HGNC symbol
- TXN2
- Aliases
- TXN; MTRX; TRX2; MT-TRX; COXPD29
- Common name
- thioredoxin 2
- Description
- This nuclear gene encodes a mitochondrial member of the thioredoxin family, a group of small multifunctional redox-active proteins. The encoded protein may play important roles in the regulation of the mitochondrial membrane potential and in protection against oxidant-induced apoptosis. [provided by RefSeq, Jul 2008]
- Cytogenetic Location
- 22q12.3
- UCSC Genome Browser
- View 22q12.3 on the UCSC genome browser
- OMIM
- 609063
- Ensembl
- ENSG00000100348
- UniProt/Swiss-Prot
- B4DX69_HUMAN
- Entrez Gene
- 25828
- UniGene
- 211929
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
- Caenorhabditis elegans
- trx-2
- Danio rerio
- txn2
- Drosophila melanogaster
- CG8517
- Drosophila melanogaster
- CG3719
- Drosophila melanogaster
- CG8993
- Mus musculus
- Txn2
- Rattus norvegicus
- Txn2
Studies (1)
Significant/Non-significant: 0/1
- Longevity Association
- Non-significant
- Population
- Danish
- Study Design
- 38 genes (311 SNPs) belonging to pro-antioxidant pathways were investigated for the association with physical and cognitive performances in a Cohort of 1089 Danish nonagenarians. For each gene analyzed in the pro-antioxidant pathway, the influence on longitudinal survival was tested.
- Conclusions
- No gene found associated with a functional phenotype showed a corresponding association with survival in the whole cohort. NDUFS1, TXNRD1, SOD2 and UCP3 were found significantly associated with lifespan in the female cohort. No association with survival was reported in males for genes belonging to the pro-oxidant pathway here analyzed.
- Indentifier
- rs12159295
- Reference