LongevityMap Gene
Gene details
- HGNC symbol
- TRIM25
- Aliases
- EFP; Z147; RNF147; ZNF147
- Common name
- tripartite motif containing 25
- Description
- The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to the cytoplasm. The presence of potential DNA-binding and dimerization-transactivation domains suggests that this protein may act as a transcription factor, similar to several other members of the TRIM family. Expression of the gene is upregulated in response to estrogen, and it is thought to mediate estrogen actions in breast cancer as a primary response gene. [provided by RefSeq, Jul 2008]
- Cytogenetic Location
- 17q22
- UCSC Genome Browser
- View 17q22 on the UCSC genome browser
- OMIM
- 600453
- Ensembl
- ENSG00000121060
- UniProt/Swiss-Prot
- TRI25_HUMAN
- Entrez Gene
- 7706
- UniGene
- 528952
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
Studies (1)
Significant/Non-significant: 1/0
- Longevity Association
- Significant
- Population
- American (Caucasian)
- Study Design
- Genome-wide association study in 801 centenarians and 914 healthy controls
- Conclusions
- 281 SNPs were found to discriminate between cases and controls
- Indentifier
- rs205499
- Reference