LongevityMap Gene
Gene details
- HGNC symbol
- TOX3
- Aliases
- CAGF9; TNRC9
- Common name
- TOX high mobility group box family member 3
- Description
- The protein encoded by this gene contains an HMG-box, indicating that it may be involved in bending and unwinding of DNA and alteration of chromatin structure. The C-terminus of the encoded protein is glutamine-rich due to CAG repeats in the coding sequence. A minor allele of this gene has been implicated in an elevated risk of breast cancer. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Apr 2009]
- Cytogenetic Location
- 16q12.1
- UCSC Genome Browser
- View 16q12.1 on the UCSC genome browser
- OMIM
- 611416
- Ensembl
- ENSG00000103460
- UniProt/Swiss-Prot
- TOX3_HUMAN
- Entrez Gene
- 27324
- UniGene
- 132574
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
- Caenorhabditis elegans
- hmg-6
- Danio rerio
- tox3
- Drosophila melanogaster
- CG12104
- Mus musculus
- Tox3
- Rattus norvegicus
- Tox3
- Saccharomyces cerevisiae
- POB3
Studies (1)
Significant/Non-significant: 0/1
- Longevity Association
- Non-significant
- Population
- Dutch
- Study Design
- A set of alleles associated with age-related diseases was tested for association with human longevity in 723 nonagenarian siblings and 721 unrelated younger controls plus 979 singleton individuals >85 years of age and 1,167 younger controls
- Conclusions
- No differences were observed in disease risk allele frequency between long-lived individuals and controls. No individual allele was significantly associated with survival to old age after controlling for multiple testing.
- Indentifier
- rs8051542
- Reference