LongevityMap Gene
Gene details
- HGNC symbol
- TOX
- Aliases
- TOX1
- Common name
- thymocyte selection associated high mobility group box
- Description
- The protein encoded by this gene contains a HMG box DNA binding domain. HMG boxes are found in many eukaryotic proteins involved in chromatin assembly, transcription and replication. This protein may function to regulate T-cell development.[provided by RefSeq, Apr 2009]
- Cytogenetic Location
- 8q12.1
- UCSC Genome Browser
- View 8q12.1 on the UCSC genome browser
- OMIM
- 606863
- Ensembl
- ENSG00000198846
- UniProt/Swiss-Prot
- TOX_HUMAN
- Entrez Gene
- 9760
- UniGene
- 491805
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
- Caenorhabditis elegans
- hmg-6
- Danio rerio
- tox
- Drosophila melanogaster
- CG12104
- Mus musculus
- Tox
- Rattus norvegicus
- Tox
- Saccharomyces cerevisiae
- POB3
Studies (1)
Significant/Non-significant: 1/0
- Longevity Association
- Significant
- Population
- American (Caucasian)
- Study Design
- Genome-wide association study in 801 centenarians and 914 healthy controls
- Conclusions
- 281 SNPs were found to discriminate between cases and controls
- Indentifier
- rs10957071
- Reference