LongevityMap Gene

Gene details

HGNC symbol: TNFSF8
Aliases: CD153; CD30L; CD30LG; TNLG3A
Common name: TNF superfamily member 8
Description: The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF8/CD30, which is a cell surface antigen and a marker for Hodgkin lymphoma and related hematologic malignancies. The engagement of this cytokine expressed on B cell surface plays an inhibitory role in modulating Ig class switch. This cytokine was shown to enhance cell proliferation of some lymphoma cell lines, while to induce cell death and reduce cell proliferation of other lymphoma cell lines. The pleiotropic biologic activities of this cytokine on different CD30+ lymphoma cell lines may play a pathophysiologic role in Hodgkin's and some non-Hodgkin's lymphomas. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
Cytogenetic Location: 9q32-q33.1
UCSC Genome Browser: View 9q32-q33.1 on the UCSC genome browser
OMIM: 603875
Ensembl: ENSG00000106952
UniProt/Swiss-Prot: A0A087X228_HUMAN
Entrez Gene: 944
UniGene: 494901
1000 Genomes: 1000 Genomes

Significant/Non-significant: 1/0

Longevity Association

Significant

Population

American (Caucasian)

Study Design

Genome-wide association study in 801 centenarians and 914 healthy controls

Conclusions

281 SNPs were found to discriminate between cases and controls

Indentifier

rs3181360

Reference