LongevityMap Gene

Gene details

HGNC symbol: TNFRSF11A
Aliases: FEO; OFE; ODFR; OSTS; PDB2; RANK; CD265; OPTB7; TRANCER; LOH18CR1
Common name: TNF receptor superfamily member 11a
Description: The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptors can interact with various TRAF family proteins, through which this receptor induces the activation of NF-kappa B and MAPK8/JNK. This receptor and its ligand are important regulators of the interaction between T cells and dendritic cells. This receptor is also an essential mediator for osteoclast and lymph node development. Mutations at this locus have been associated with familial expansile osteolysis, autosomal recessive osteopetrosis, and Paget disease of bone. Alternatively spliced transcript variants have been described for this locus. [provided by RefSeq, Aug 2012]
Cytogenetic Location: 18q21.33
UCSC Genome Browser: View 18q21.33 on the UCSC genome browser
OMIM: 603499
Ensembl: ENSG00000141655
UniProt/Swiss-Prot: TNR11_HUMAN
Entrez Gene: 8792
UniGene: 204044
1000 Genomes: 1000 Genomes

Significant/Non-significant: 1/0

Longevity Association

Significant

Population

American (Caucasian)

Study Design

Genome-wide association study in 801 centenarians and 914 healthy controls

Conclusions

281 SNPs were found to discriminate between cases and controls

Indentifier

rs8083511

Reference