LongevityMap Gene
Gene details
- HGNC symbol
- TMEM230
- Aliases
- HSPC274; C20orf30; dJ1116H23.2.1
- Common name
- transmembrane protein 230
- Description
- This gene encodes a multi-pass transmembrane protein that belongs to the TMEM134/TMEM230 protein family. The encoded protein localizes to secretory and recycling vesicle in the neuron and may be involved in synaptic vesicles trafficking and recycling. Mutations in this gene may be linked to familial Parkinson's disease. [provided by RefSeq, Mar 2017]
- Cytogenetic Location
- 20p13-p12.3
- UCSC Genome Browser
- View 20p13-p12.3 on the UCSC genome browser
- OMIM
- 617019
- Ensembl
- ENSG00000089063
- UniProt/Swiss-Prot
- A0A087WTT2_HUMAN
- Entrez Gene
- 29058
- UniGene
- 472024
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
Studies (1)
Significant/Non-significant: 0/1
- Longevity Association
- Non-significant
- Population
- Danish
- Study Design
- 592 SNPs from 77 genes involved in nine sub-processes were analyzed in 1089 long-lived and 736 middle-aged Danes. Then, a replicated study was carried out in a German cohort.
- Conclusions
- The results did not remain significant after correction. The findings drawn from the Danish cohort were not replicated in German samples.
- Indentifier
- rs3729558
- Reference