LongevityMap Gene
Gene details
- HGNC symbol
- TMEFF2
- Aliases
- TR; HPP1; TPEF; TR-2; TENB2; CT120.2
- Common name
- transmembrane protein with EGF like and two follistatin like domains 2
- Description
- This gene encodes a member of the tomoregulin family of transmembrane proteins. This protein has been shown to function as both an oncogene and a tumor suppressor depending on the cellular context and may regulate prostate cancer cell invasion. Multiple soluble forms of this protein have been identified that arise from both an alternative splice variant and ectodomain shedding. Additionally, this gene has been found to be hypermethylated in multiple cancer types. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]
- Cytogenetic Location
- 2q32.3
- UCSC Genome Browser
- View 2q32.3 on the UCSC genome browser
- OMIM
- 605734
- Ensembl
- ENSG00000144339
- UniProt/Swiss-Prot
- TEFF2_HUMAN
- Entrez Gene
- 23671
- UniGene
- 144513
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
Studies (1)
Significant/Non-significant: 0/1
- Longevity Association
- Non-significant
- Population
- Dutch
- Study Design
- A set of alleles associated with age-related diseases was tested for association with human longevity in 723 nonagenarian siblings and 721 unrelated younger controls plus 979 singleton individuals >85 years of age and 1,167 younger controls
- Conclusions
- No differences were observed in disease risk allele frequency between long-lived individuals and controls. No individual allele was significantly associated with survival to old age after controlling for multiple testing.
- Indentifier
- rs10497721
- Reference