LongevityMap Gene

Gene details

HGNC symbol: TFAM
Aliases: TCF6; MTTF1; MTTFA; TCF6L1; TCF6L2; TCF6L3; MTDPS15
Common name: transcription factor A, mitochondrial
Description: This gene encodes a key mitochondrial transcription factor containing two high mobility group motifs. The encoded protein also functions in mitochondrial DNA replication and repair. Sequence polymorphisms in this gene are associated with Alzheimer's and Parkinson's diseases. There are pseudogenes for this gene on chromosomes 6, 7, and 11. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
Cytogenetic Location: 10q21.1
UCSC Genome Browser: View 10q21.1 on the UCSC genome browser
OMIM: 600438
Ensembl: ENSG00000108064
UniProt/Swiss-Prot: E5KSU5_HUMAN
Entrez Gene: 7019
UniGene: 594250
1000 Genomes: 1000 Genomes

CellAge gene expression

Significant/Non-significant: 0/2

Longevity Association: Non-significant
Population: Spanish
Study Design: The association between five common polymorphisms in genes of this pathway and extreme longevity were examined using a case (107 centenarian, 100–111 years, 89 female)-control (284 young adults, ≤50 years, 150 female) design.
Conclusions: The studied genetic variants of the PPARD-PPARGC1A-NRF-TFAM pathway were not associated with extreme longevity. A marginal association could exist for rs1937 in TFAM (p=0.003).
Indentifier

Longevity Association: Non-significant
Population: Danish
Study Design: 592 SNPs from 77 genes involved in nine sub-processes were analyzed in 1089 long-lived and 736 middle-aged Danes. Then, a replicated study was carried out in a German cohort.
Conclusions: The results did not remain significant after correction. The findings drawn from the Danish cohort were not replicated in German samples.
Indentifier