LongevityMap Gene
Gene details
- HGNC symbol
- TENM4
- Aliases
- Doc4; ETM5; ODZ4; TNM4; ten-4; Ten-M4
- Common name
- teneurin transmembrane protein 4
- Description
- The protein encoded by this gene plays a role in establishing proper neuronal connectivity during development. Defects in this gene have been associated with hereditary essential tremor-5. [provided by RefSeq, Oct 2016]
- Cytogenetic Location
- 11q14.1
- UCSC Genome Browser
- View 11q14.1 on the UCSC genome browser
- OMIM
- 610084
- Ensembl
- ENSG00000149256
- UniProt/Swiss-Prot
- TEN4_HUMAN
- Entrez Gene
- 26011
- UniGene
- 213087
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
Studies (2)
Significant/Non-significant: 1/1
Study 1
- Longevity Association
- Significant
- Population
- American (Caucasian)
- Study Design
- Genome-wide association study in 801 centenarians and 914 healthy controls
- Conclusions
- 281 SNPs were found to discriminate between cases and controls
- Indentifier
- rs563384
- Reference
Study 2
- Longevity Association
- Non-significant
- Population
- Italian
- Study Design
- Genome-wide association study on 410 long-living individuals (age range, 90–109 years) and 553 young control individuals (age range, 18–48 years) using 318,237 SNPs. An independent population with 116 long-lived individuals and 160 controls was used for replication purposes.
- Conclusions
- A total of 67 SNPs were identified with an indication of potentially being associated with longevity (p < 1 × 10−4), though 66 were not further validated
- Indentifier
- rs11237644
- Reference