LongevityMap Gene
Gene details
- HGNC symbol
- TCF7L2
- Aliases
- TCF4; TCF-4
- Common name
- transcription factor 7 like 2
- Description
- This gene encodes a high mobility group (HMG) box-containing transcription factor that plays a key role in the Wnt signaling pathway. The protein has been implicated in blood glucose homeostasis. Genetic variants of this gene are associated with increased risk of type 2 diabetes. Several transcript variants encoding multiple different isoforms have been found for this gene.[provided by RefSeq, Oct 2010]
- Cytogenetic Location
- 10q25.2-q25.3
- UCSC Genome Browser
- View 10q25.2-q25.3 on the UCSC genome browser
- OMIM
- 602228
- Ensembl
- ENSG00000148737
- UniProt/Swiss-Prot
- A0A0A0MTL7_HUMAN
- Entrez Gene
- 6934
- UniGene
- 593995
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
- Caenorhabditis elegans
- pop-1
- Danio rerio
- tcf7l2
- Drosophila melanogaster
- pan
- Mus musculus
- Tcf7l2
- Rattus norvegicus
- Tcf7l2
Studies (1)
Significant/Non-significant: 0/1
- Longevity Association
- Non-significant
- Population
- Dutch
- Study Design
- A set of alleles associated with age-related diseases was tested for association with human longevity in 723 nonagenarian siblings and 721 unrelated younger controls plus 979 singleton individuals >85 years of age and 1,167 younger controls
- Conclusions
- No differences were observed in disease risk allele frequency between long-lived individuals and controls. No individual allele was significantly associated with survival to old age after controlling for multiple testing.
- Indentifier
- rs7903146
- Reference