LongevityMap Gene
Gene details
- HGNC symbol
- TCF19
- Aliases
- SC1; TCF-19
- Common name
- transcription factor 19
- Description
- This gene encodes a protein that contains a PHD-type zinc finger domain and likely functions as a transcription factor. The encoded protein plays a role proliferation and apoptosis of pancreatic beta cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
- Cytogenetic Location
- 6p21.33
- UCSC Genome Browser
- View 6p21.33 on the UCSC genome browser
- OMIM
- 600912
- Ensembl
- ENSG00000137310
- UniProt/Swiss-Prot
- TCF19_HUMAN
- Entrez Gene
- 6941
- UniGene
- 584807
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
In other databases
- CellAge gene expression
- This gene is present as TCF19
Studies (1)
Significant/Non-significant: 0/1
- Longevity Association
- Non-significant
- Population
- German
- Study Design
- Genome-wide association study comparing 664,472 autosomal SNPs in 763 long-lived individuals (mean age: 99.7 years) and 1085 controls (mean age: 60.2 years). Top SNPs from the GWAS were further investigated in an independent German sample comprised of 754 long-lived individuals (mean age: 96.9 years) and 860 controls (mean age: 67.3 years).
- Conclusions
- Thirty-two SNPs previously associated with longevity were not associated with longevity in this study
- Indentifier
- rs2073724
- Reference