LongevityMap Gene
Gene details
- HGNC symbol
- TBXAS1
- Aliases
- TS; TXS; CYP5; THAS; TXAS; CYP5A1; GHOSAL; BDPLT14
- Common name
- thromboxane A synthase 1
- Description
- This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the conversion of prostglandin H2 to thromboxane A2, a potent vasoconstrictor and inducer of platelet aggregation. The enzyme plays a role in several pathophysiological processes including hemostasis, cardiovascular disease, and stroke. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
- Cytogenetic Location
- 7q34
- UCSC Genome Browser
- View 7q34 on the UCSC genome browser
- OMIM
- 274180
- Ensembl
- ENSG00000059377
- UniProt/Swiss-Prot
- A0A0A0MSK3_HUMAN
- Entrez Gene
- 6916
- UniGene
- 520757
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
- Caenorhabditis elegans
- cyp-25A4
- Caenorhabditis elegans
- cyp-13A11
- Caenorhabditis elegans
- cyp-13A12
- Caenorhabditis elegans
- cyp-25A6
- Caenorhabditis elegans
- cyp-25A1
- Caenorhabditis elegans
- cyp-13B1
- Caenorhabditis elegans
- cyp-13A10
- Caenorhabditis elegans
- cyp-25A2
- Caenorhabditis elegans
- cyp-43A1
- Caenorhabditis elegans
- cyp-13B2
- Caenorhabditis elegans
- cyp-13A4
- Caenorhabditis elegans
- cyp-13A1
- Caenorhabditis elegans
- cyp-13A7
- Caenorhabditis elegans
- cyp-25A3
- Caenorhabditis elegans
- cyp-13A3
- Caenorhabditis elegans
- cyp-13A2
- Caenorhabditis elegans
- cyp-13A5
- Caenorhabditis elegans
- cyp-13A6
- Caenorhabditis elegans
- cyp-13A8
- Danio rerio
- tbxas1
- Drosophila melanogaster
- Cyp6a22
- Drosophila melanogaster
- Cyp6a17
- Drosophila melanogaster
- Cyp6a18
- Drosophila melanogaster
- Cyp9b1
- Drosophila melanogaster
- Cyp9b2
- Drosophila melanogaster
- Cyp6a13
- Drosophila melanogaster
- Cyp6g1
- Drosophila melanogaster
- Cyp6u1
- Drosophila melanogaster
- Cyp6a2
- Drosophila melanogaster
- Cyp6v1
- Drosophila melanogaster
- Cyp6t1
- Drosophila melanogaster
- Cyp6w1
- Drosophila melanogaster
- Cyp6a9
- Drosophila melanogaster
- Cyp6g2
- Drosophila melanogaster
- Cyp317a1
- Drosophila melanogaster
- Cyp9c1
- Drosophila melanogaster
- Cyp9f2
- Drosophila melanogaster
- Cyp6t3
- Drosophila melanogaster
- Cyp6a8
- Drosophila melanogaster
- Cyp9h1
- Drosophila melanogaster
- Cyp6a21
- Drosophila melanogaster
- Cyp6a23
- Drosophila melanogaster
- Cyp6a19
- Mus musculus
- Tbxas1
- Rattus norvegicus
- Tbxas1
In other databases
- GenAge model organism genes
- A homolog of this gene for Caenorhabditis elegans is present as cyp-13B1
- GenAge microarray genes
- This gene is present as TBXAS1
Studies (1)
Significant/Non-significant: 1/0
- Longevity Association
- Significant
- Population
- American (Caucasian)
- Study Design
- Genome-wide association study in 801 centenarians and 914 healthy controls
- Conclusions
- 281 SNPs were found to discriminate between cases and controls
- Indentifier
- rs1557967
- Reference