LongevityMap Gene

Gene details

HGNC symbol
TBXAS1 
Aliases
TS; TXS; CYP5; THAS; TXAS; CYP5A1; GHOSAL; BDPLT14 
Common name
thromboxane A synthase 1 
Description
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the conversion of prostglandin H2 to thromboxane A2, a potent vasoconstrictor and inducer of platelet aggregation. The enzyme plays a role in several pathophysiological processes including hemostasis, cardiovascular disease, and stroke. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
Cytogenetic Location
7q34
UCSC Genome Browser
View 7q34 on the UCSC genome browser
OMIM
274180
Ensembl
ENSG00000059377
UniProt/Swiss-Prot
A0A0A0MSK3_HUMAN
Entrez Gene
6916
UniGene
520757
1000 Genomes
1000 Genomes

Homologs in model organisms

Caenorhabditis elegans
cyp-25A4
Caenorhabditis elegans
cyp-13A11
Caenorhabditis elegans
cyp-13A12
Caenorhabditis elegans
cyp-25A6
Caenorhabditis elegans
cyp-25A1
Caenorhabditis elegans
cyp-13B1
Caenorhabditis elegans
cyp-13A10
Caenorhabditis elegans
cyp-25A2
Caenorhabditis elegans
cyp-43A1
Caenorhabditis elegans
cyp-13B2
Caenorhabditis elegans
cyp-13A4
Caenorhabditis elegans
cyp-13A1
Caenorhabditis elegans
cyp-13A7
Caenorhabditis elegans
cyp-25A3
Caenorhabditis elegans
cyp-13A3
Caenorhabditis elegans
cyp-13A2
Caenorhabditis elegans
cyp-13A5
Caenorhabditis elegans
cyp-13A6
Caenorhabditis elegans
cyp-13A8
Danio rerio
tbxas1
Drosophila melanogaster
Cyp6a22
Drosophila melanogaster
Cyp6a17
Drosophila melanogaster
Cyp6a18
Drosophila melanogaster
Cyp9b1
Drosophila melanogaster
Cyp9b2
Drosophila melanogaster
Cyp6a13
Drosophila melanogaster
Cyp6g1
Drosophila melanogaster
Cyp6u1
Drosophila melanogaster
Cyp6a2
Drosophila melanogaster
Cyp6v1
Drosophila melanogaster
Cyp6t1
Drosophila melanogaster
Cyp6w1
Drosophila melanogaster
Cyp6a9
Drosophila melanogaster
Cyp6g2
Drosophila melanogaster
Cyp317a1
Drosophila melanogaster
Cyp9c1
Drosophila melanogaster
Cyp9f2
Drosophila melanogaster
Cyp6t3
Drosophila melanogaster
Cyp6a8
Drosophila melanogaster
Cyp9h1
Drosophila melanogaster
Cyp6a21
Drosophila melanogaster
Cyp6a23
Drosophila melanogaster
Cyp6a19
Mus musculus
Tbxas1
Rattus norvegicus
Tbxas1

In other databases

GenAge model organism genes
  • A homolog of this gene for Caenorhabditis elegans is present as cyp-13B1
GenAge microarray genes
  • This gene is present as TBXAS1

Studies (1)

Significant/Non-significant: 1/0

Longevity Association
Significant
Population
American (Caucasian)
Study Design
Genome-wide association study in 801 centenarians and 914 healthy controls
Conclusions
281 SNPs were found to discriminate between cases and controls
Indentifier
rs1557967
Reference