LongevityMap Gene
Gene details
- HGNC symbol
- SYT13
- Aliases
- Common name
- synaptotagmin 13
- Description
- This gene encodes a member of the large synaptotagmin protein family. Family members have an extracellular N-terminal transmembrane domain and a cytoplasmic C terminus with two tandem C2 domains (C2A and C2B). Synaptotogmin family members can form homo- and heteromeric complexes with each other. They also have different biochemical properties and developmental profiles, and patterns of tissue distribution. Synaptotagmins function as membrane traffickers in multicellular organisms. Two alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Oct 2011]
- Cytogenetic Location
- 11p11.2
- UCSC Genome Browser
- View 11p11.2 on the UCSC genome browser
- OMIM
- 607716
- Ensembl
- ENSG00000019505
- UniProt/Swiss-Prot
- SYT13_HUMAN
- Entrez Gene
- 57586
- UniGene
- 436643
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
Studies (1)
Significant/Non-significant: 1/0
- Longevity Association
- Significant
- Population
- American (Caucasian)
- Study Design
- Genome-wide association study in 801 centenarians and 914 healthy controls
- Conclusions
- 281 SNPs were found to discriminate between cases and controls
- Indentifier
- rs4755936
- Reference