LongevityMap Gene
Gene details
- HGNC symbol
- SYK
- Aliases
- p72-Syk
- Common name
- spleen associated tyrosine kinase
- Description
- This gene encodes a member of the family of non-receptor type Tyr protein kinases. This protein is widely expressed in hematopoietic cells and is involved in coupling activated immunoreceptors to downstream signaling events that mediate diverse cellular responses, including proliferation, differentiation, and phagocytosis. It is thought to be a modulator of epithelial cell growth and a potential tumour suppressor in human breast carcinomas. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]
- Cytogenetic Location
- 9q22.2
- UCSC Genome Browser
- View 9q22.2 on the UCSC genome browser
- OMIM
- 600085
- Ensembl
- ENSG00000165025
- UniProt/Swiss-Prot
- A0A024R244_HUMAN
- Entrez Gene
- 6850
- UniGene
- 371720
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
In other databases
- CellAge
- This gene is present as SYK
Studies (1)
Significant/Non-significant: 0/1
- Longevity Association
- Non-significant
- Population
- Dutch
- Study Design
- Genome-wide association study in 403 unrelated nonagenarians from long-living families and 1670 younger controls. Strongest candidates were then investigated in a meta-analysis of 4149 nonagenarian cases and 7582 younger controls.
- Conclusions
- No SNP reached significance in the GWAS but 62 SNPs, many in genes, had an indicative association with survival into old age. Of these 62 SNPs then studied in the meta-analysis, 61 were not significant.
- Indentifier
- rs2290889
- Reference