LongevityMap Gene
Gene details
- HGNC symbol
- SULT1A1
- Aliases
- PST; STP; STP1; P-PST; ST1A1; ST1A3; TSPST1; HAST1/HAST2
- Common name
- sulfotransferase family 1A member 1
- Description
- Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes one of two phenol sulfotransferases with thermostable enzyme activity. Multiple alternatively spliced variants that encode two isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
- Cytogenetic Location
- 16p11.2
- UCSC Genome Browser
- View 16p11.2 on the UCSC genome browser
- OMIM
- 171150
- Ensembl
- ENSG00000196502
- UniProt/Swiss-Prot
- ST1A1_HUMAN
- Entrez Gene
- 6817
- UniGene
- 567342
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
In other databases
- GenDR gene expression
- A homolog of this gene for Mus musculus is present as Sult1a1
Studies (2)
Significant/Non-significant: 1/1
Study 1
- Longevity Association
- Significant
- Population
- English (Caucasian) and Nigerian
- Study Design
- 638G/A (Arg 213 to His) SNP was examined in Caucasian (n=293; 12-99 years old) and African (Nigerian, n=52) populations
- Conclusions
- A significant age-related difference in genotype was observed within Caucasian population, with increasing incidence of SULT1A11 homozygosity and decreasing incidence of SULT1A12 homozygosity with increasing age
- Indentifier
- 638G/A
- Reference
Study 2
- Longevity Association
- Non-significant
- Population
- Italian (Southern)
- Study Design
- A two-stage case-control study was performed to identify the association between longevity and variation of in homeostasis regulation pathway genes. 317 SNPs in 104 genes were analyzed in 78 cases (≥90 years, median age 98 years, 42 females) and 71 controls (<90 years, median age 67 years, 32 females) in stage 1. Then, 31 candidate SNPs identified in stage 1 (π markers = 0.1) were analyzed in an independent sample composed by 288 cases (≥90 years, median age 92 years, 163 females) and 554 controls (<90 years, median age 67 years, 277 females).
- Conclusions
- After adjustment for multiple testing, no significant association was identified between various SNPs and longevity.
- Indentifier
- rs4149396
- Reference