LongevityMap Gene
Gene details
- HGNC symbol
- STK24
- Aliases
- MST3; STK3; MST3B; STE20; HEL-S-95
- Common name
- serine/threonine kinase 24
- Description
- This gene encodes a serine/threonine protein kinase that functions upstream of mitogen-activated protein kinase (MAPK) signaling. The encoded protein is cleaved into two chains by caspases; the N-terminal fragment (MST3/N) translocates to the nucleus and promotes programmed cells death. There is a pseudogene for this gene on chromosome X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013]
- Cytogenetic Location
- 13q32.2
- UCSC Genome Browser
- View 13q32.2 on the UCSC genome browser
- OMIM
- 604984
- Ensembl
- ENSG00000102572
- UniProt/Swiss-Prot
- B4DR80_HUMAN
- Entrez Gene
- 8428
- UniGene
- 508514
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
- Caenorhabditis elegans
- gck-1
- Danio rerio
- stk24b
- Drosophila melanogaster
- GckIII
- Mus musculus
- Stk24
- Rattus norvegicus
- Stk24
- Saccharomyces cerevisiae
- KIC1
Studies (1)
Significant/Non-significant: 1/0
- Longevity Association
- Significant
- Population
- American (Caucasian)
- Study Design
- Genome-wide association study using 1,471 genotyped participants from the Framingham Heart Study, of which 1,173 individuals had known lifespans, plus 517 individuals from the Offspring cohort for validating connections between longevity and genetic variants
- Conclusions
- A total of 27 SNPs, including in CDH4, SVEP1, CACNA1C, CARS, STK24, C7orf50, PARVG, NCAM2, PPP2R2C, NLRC5, BTBD9, RAC2, TGFA, KIAA0649, ABCC4, CLSTN2, FAM19A5 and RUNX3, were identified at the intersection of various statistical procedures
- Indentifier
- rs9517320
- Reference