LongevityMap Gene
Gene details
- HGNC symbol
- ST6GAL1
- Aliases
- ST6N; SIAT1; ST6GalI
- Common name
- ST6 beta-galactoside alpha-2,6-sialyltransferase 1
- Description
- This gene encodes a member of glycosyltransferase family 29. The encoded protein is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. The protein, which is normally found in the Golgi but can be proteolytically processed to a soluble form, is involved in the generation of the cell-surface carbohydrate determinants and differentiation antigens HB-6, CD75, and CD76. This gene has been incorrectly referred to as CD75. Three transcript variants encoding two different isoforms have been described. [provided by RefSeq, Aug 2009]
- Cytogenetic Location
- 3q27.3
- UCSC Genome Browser
- View 3q27.3 on the UCSC genome browser
- OMIM
- 109675
- Ensembl
- ENSG00000073849
- UniProt/Swiss-Prot
- SIAT1_HUMAN
- Entrez Gene
- 6480
- UniGene
- 207459
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
Studies (1)
Significant/Non-significant: 0/1
- Longevity Association
- Non-significant
- Population
- American, English, Irish
- Study Design
- 10 late-onset Alzheimer's disease genes were tested for association with human aging in the dataset (1385 samples with documented age at death, age range: 58–108 years; mean age at death: 80.2 years) using the most significant SNPs found in the previous studies. A set of 41 tentative SNPs span the genome were identified in this study.
- Conclusions
- Some signals were at best tentative but may merit study in larger sample sets
- Indentifier
- rs4686837
- Reference