LongevityMap Gene
Gene details
- HGNC symbol
- SPIB
- Aliases
- SPI-B
- Common name
- Spi-B transcription factor
- Description
- The protein encoded by this gene is a transcriptional activator that binds to the PU-box (5'-GAGGAA-3') and acts as a lymphoid-specific enhancer. Four transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
- Cytogenetic Location
- 19q13.33
- UCSC Genome Browser
- View 19q13.33 on the UCSC genome browser
- OMIM
- 606802
- Ensembl
- ENSG00000269404
- UniProt/Swiss-Prot
- A0A024R4I5_HUMAN
- Entrez Gene
- 6689
- UniGene
- 437905
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
Studies (1)
Significant/Non-significant: 0/1
- Longevity Association
- Non-significant
- Population
- Danish
- Study Design
- 592 SNPs from 77 genes involved in nine sub-processes were analyzed in 1089 long-lived and 736 middle-aged Danes. Then, a replicated study was carried out in a German cohort.
- Conclusions
- The results did not remain significant after correction. The findings drawn from the Danish cohort were not replicated in German samples.
- Indentifier
- rs2445837
- Reference