LongevityMap Gene

Gene details

HGNC symbol: SORCS2
Aliases
Common name: sortilin related VPS10 domain containing receptor 2
Description: This gene encodes one family member of vacuolar protein sorting 10 (VPS10) domain-containing receptor proteins. The VPS10 domain name comes from the yeast carboxypeptidase Y sorting receptor Vps10 protein. Members of this gene family are large with many exons but the CDS lengths are usually less than 3700 nt. Very large introns typically separate the exons encoding the VPS10 domain; the remaining exons are separated by much smaller-sized introns. These genes are strongly expressed in the central nervous system. [provided by RefSeq, Jul 2008]
Cytogenetic Location: 4p16.1
UCSC Genome Browser: View 4p16.1 on the UCSC genome browser
OMIM: 606284
Ensembl: ENSG00000184985
UniProt/Swiss-Prot: SORC2_HUMAN
Entrez Gene: 57537
UniGene: 479099
1000 Genomes: 1000 Genomes

GenAge model organism genes

Significant/Non-significant: 1/0

Longevity Association

Significant

Population

American (Caucasian)

Study Design

Genome-wide association study in 801 centenarians and 914 healthy controls

Conclusions

281 SNPs were found to discriminate between cases and controls

Indentifier

rs6812745

Reference