LongevityMap Gene
Gene details
- HGNC symbol
- SLCO1B1
- Aliases
- LST1; HBLRR; LST-1; OATP2; OATPC; OATP-C; OATP1B1; SLC21A6
- Common name
- solute carrier organic anion transporter family member 1B1
- Description
- This gene encodes a liver-specific member of the organic anion transporter family. The encoded protein is a transmembrane receptor that mediates the sodium-independent uptake of numerous endogenous compounds including bilirubin, 17-beta-glucuronosyl estradiol and leukotriene C4. This protein is also involved in the removal of drug compounds such as statins, bromosulfophthalein and rifampin from the blood into the hepatocytes. Polymorphisms in the gene encoding this protein are associated with impaired transporter function. [provided by RefSeq, Mar 2009]
- Cytogenetic Location
- 12p12.1
- UCSC Genome Browser
- View 12p12.1 on the UCSC genome browser
- OMIM
- 604843
- Ensembl
- ENSG00000134538
- UniProt/Swiss-Prot
- A0A024RAU7_HUMAN
- Entrez Gene
- 10599
- UniGene
- 449738
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
Studies (1)
Significant/Non-significant: 0/1
- Longevity Association
- Non-significant
- Population
- American, English, Irish
- Study Design
- 10 late-onset Alzheimer's disease genes were tested for association with human aging in the dataset (1385 samples with documented age at death, age range: 58–108 years; mean age at death: 80.2 years) using the most significant SNPs found in the previous studies. A set of 41 tentative SNPs span the genome were identified in this study.
- Conclusions
- Some signals were at best tentative but may merit study in larger sample sets
- Indentifier
- rs987839
- Reference