LongevityMap Gene
Gene details
- HGNC symbol
- SLC39A10
- Aliases
- LZT-Hs2
- Common name
- solute carrier family 39 member 10
- Description
- Zinc is an essential cofactor for hundreds of enzymes. It is involved in protein, nucleic acid, carbohydrate, and lipid metabolism, as well as in the control of gene transcription, growth, development, and differentiation. SLC39A10 belongs to a subfamily of proteins that show structural characteristics of zinc transporters (Taylor and Nicholson, 2003 [PubMed 12659941]).[supplied by OMIM, Mar 2008]
- Cytogenetic Location
- 2q32.3
- UCSC Genome Browser
- View 2q32.3 on the UCSC genome browser
- OMIM
- 608733
- Ensembl
- ENSG00000196950
- UniProt/Swiss-Prot
- A0A024R3W5_HUMAN
- Entrez Gene
- 57181
- UniGene
- 650158
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
- Danio rerio
- slc39a10
- Drosophila melanogaster
- foi
- Mus musculus
- Slc39a10
- Rattus norvegicus
- Slc39a10
- Saccharomyces cerevisiae
- YKE4
Studies (1)
Significant/Non-significant: 0/1
- Longevity Association
- Non-significant
- Population
- Dutch
- Study Design
- Genome-wide association study in 403 unrelated nonagenarians from long-living families and 1670 younger controls. Strongest candidates were then investigated in a meta-analysis of 4149 nonagenarian cases and 7582 younger controls.
- Conclusions
- No SNP reached significance in the GWAS but 62 SNPs, many in genes, had an indicative association with survival into old age. Of these 62 SNPs then studied in the meta-analysis, 61 were not significant.
- Indentifier
- rs10931700
- Reference