LongevityMap Gene
Gene details
- HGNC symbol
- SLC30A8
- Aliases
- ZNT8; ZnT-8
- Common name
- solute carrier family 30 member 8
- Description
- The protein encoded by this gene is a zinc efflux transporter involved in the accumulation of zinc in intracellular vesicles. This gene is expressed at a high level only in the pancreas, particularly in islets of Langerhans. The encoded protein colocalizes with insulin in the secretory pathway granules of the insulin-secreting INS-1 cells. Allelic variants of this gene exist that confer susceptibility to diabetes mellitus, noninsulin-dependent (NIDDM). Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2010]
- Cytogenetic Location
- 8q24.11
- UCSC Genome Browser
- View 8q24.11 on the UCSC genome browser
- OMIM
- 611145
- Ensembl
- ENSG00000164756
- UniProt/Swiss-Prot
- ZNT8_HUMAN
- Entrez Gene
- 169026
- UniGene
- 532270
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
- Caenorhabditis elegans
- cdf-2
- Danio rerio
- slc30a8
- Drosophila melanogaster
- ZnT35C
- Drosophila melanogaster
- ZnT33D
- Mus musculus
- Slc30a8
- Rattus norvegicus
- Slc30a8
- Saccharomyces cerevisiae
- ZRC1
- Saccharomyces cerevisiae
- COT1
Studies (1)
Significant/Non-significant: 0/1
- Longevity Association
- Non-significant
- Population
- Dutch
- Study Design
- A set of alleles associated with age-related diseases was tested for association with human longevity in 723 nonagenarian siblings and 721 unrelated younger controls plus 979 singleton individuals >85 years of age and 1,167 younger controls
- Conclusions
- No differences were observed in disease risk allele frequency between long-lived individuals and controls. No individual allele was significantly associated with survival to old age after controlling for multiple testing.
- Indentifier
- rs13266634
- Reference