LongevityMap Gene
Gene details
- HGNC symbol
- SLC25A21
- Aliases
- ODC; ODC1
- Common name
- solute carrier family 25 member 21
- Description
- SLC25A21 is a homolog of the S. cerevisiae ODC proteins, mitochondrial carriers that transport C5-C7 oxodicarboxylates across inner mitochondrial membranes. One of the species transported by ODC is 2-oxoadipate, a common intermediate in the catabolism of lysine, tryptophan, and hydroxylysine in mammals. Within mitochondria, 2-oxoadipate is converted into acetyl-CoA.[supplied by OMIM, Apr 2004]
- Cytogenetic Location
- 14q13.3
- UCSC Genome Browser
- View 14q13.3 on the UCSC genome browser
- OMIM
- 607571
- Ensembl
- ENSG00000183032
- UniProt/Swiss-Prot
- ODC_HUMAN
- Entrez Gene
- 89874
- UniGene
- 730857
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
- Caenorhabditis elegans
- R11.1
- Danio rerio
- slc25a21
- Drosophila melanogaster
- CG5254
- Drosophila melanogaster
- CG9582
- Mus musculus
- Slc25a21
- Rattus norvegicus
- Slc25a21
- Saccharomyces cerevisiae
- ODC2
- Saccharomyces cerevisiae
- ODC1
- Schizosaccharomyces pombe
- SPAC328.09
Studies (1)
Significant/Non-significant: 1/0
- Longevity Association
- Significant
- Population
- American (Caucasian)
- Study Design
- Genome-wide association study in 801 centenarians and 914 healthy controls
- Conclusions
- 281 SNPs were found to discriminate between cases and controls
- Indentifier
- rs1429842
- Reference