LongevityMap Gene

Gene details

HGNC symbol: SDC4
Aliases: SYND4
Common name: syndecan 4
Description: The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan that functions as a receptor in intracellular signaling. The encoded protein is found as a homodimer and is a member of the syndecan proteoglycan family. This gene is found on chromosome 20, while a pseudogene has been found on chromosome 22. [provided by RefSeq, Jul 2008]
Cytogenetic Location: 20q13.12
UCSC Genome Browser: View 20q13.12 on the UCSC genome browser
OMIM: 600017
Ensembl: ENSG00000124145
UniProt/Swiss-Prot: B4E1S6_HUMAN
Entrez Gene: 6385
UniGene: 632267
1000 Genomes: 1000 Genomes

Significant/Non-significant: 1/1

Longevity Association: Significant
Population: Italian (Southern)
Study Design: 11 SNPs within the SDC4 gene were tested for association with longevity in a cohort of 624 unrelated subjects (aged 64-107, 287 males and 337 females, 350 subjects > 85 years old). Then the identified longevity-associated SNPs were correlated with metabolic parameters in the subgroup of 64-85 years old.
Conclusions: rs1981429 was negatively associated with longevity (adjusted p = 0.028), high levels of triglycerides (adjusted p = 0.028) and low levels of LDL-C (adjusted p = 0.009). rs2251252 was positively correlated with longevity (adjusted p = 0.018) and high LDL-C (adjusted p = 0.022).
Indentifier

Longevity Association: Non-significant
Population: Italian (Southern)
Study Design: 11 SNPs within the SDC4 gene were tested for association with longevity in a cohort of 624 unrelated subjects (aged 64-107, 287 males and 337 females, 350 subjects > 85 years old). Then the identified longevity-associated SNPs were correlated with metabolic parameters in the subgroup of 64-85 years old.
Conclusions: After multiple test correction, those 9 SNPs were not associated with longevity or other metabolic parameters.
Indentifier