LongevityMap Gene
Gene details
- HGNC symbol
- SCN9A
- Aliases
- PN1; ETHA; NENA; SFNP; FEB3B; NE-NA; GEFSP7; HSAN2D; Nav1.7
- Common name
- sodium voltage-gated channel alpha subunit 9
- Description
- This gene encodes a voltage-gated sodium channel which plays a significant role in nociception signaling. Mutations in this gene have been associated with primary erythermalgia, channelopathy-associated insensitivity to pain, and paroxysmal extreme pain disorder. [provided by RefSeq, Aug 2009]
- Cytogenetic Location
- 2q24.3
- UCSC Genome Browser
- View 2q24.3 on the UCSC genome browser
- OMIM
- 603415
- Ensembl
- ENSG00000169432
- UniProt/Swiss-Prot
- SCN9A_HUMAN
- Entrez Gene
- 6335
- UniGene
- 439145
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
- Danio rerio
- scn1lab
- Danio rerio
- scn1a
- Drosophila melanogaster
- para
- Mus musculus
- Scn9a
- Rattus norvegicus
- Scn9a
Studies (1)
Significant/Non-significant: 0/1
- Longevity Association
- Non-significant
- Population
- Caucasians
- Study Design
- Meta-analysis of GWAS in Caucasians from four prospective cohort studies: the Age, Gene/Environment Susceptibility-Reykjavik Study, the Cardiovascular Health Study, the Framingham Heart Study, and the Rotterdam Study participating in the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium. Longevity was defined as survival to age 90 years or older (n = 1,836); the comparison group comprised cohort members who died between the ages of 55 and 80 years (n = 1,955).
- Conclusions
- There were 273 single-nucleotide polymorphism (SNP) associations with p < .0001, but none reached significance after correcting for multiple testing
- Indentifier
- rs6432908
- Reference