LongevityMap Gene
Gene details
- HGNC symbol
- RPS6
- Aliases
- S6
- Common name
- ribosomal protein S6
- Description
- Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a cytoplasmic ribosomal protein that is a component of the 40S subunit. The protein belongs to the S6E family of ribosomal proteins. It is the major substrate of protein kinases in the ribosome, with subsets of five C-terminal serine residues phosphorylated by different protein kinases. Phosphorylation is induced by a wide range of stimuli, including growth factors, tumor-promoting agents, and mitogens. Dephosphorylation occurs at growth arrest. The protein may contribute to the control of cell growth and proliferation through the selective translation of particular classes of mRNA. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]
- Cytogenetic Location
- 9p22.1
- UCSC Genome Browser
- View 9p22.1 on the UCSC genome browser
- OMIM
- 180460
- Ensembl
- ENSG00000137154
- UniProt/Swiss-Prot
- A2A3R6_HUMAN
- Entrez Gene
- 6194
- UniGene
- 408073
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
- Caenorhabditis elegans
- rps-6
- Danio rerio
- rps6
- Drosophila melanogaster
- RpS6
- Mus musculus
- Rps6
- Mus musculus
- Rps6
- Rattus norvegicus
- Rps6
- Rattus norvegicus
- Rps6
- Saccharomyces cerevisiae
- RPS6B
- Saccharomyces cerevisiae
- RPS6A
- Saccharomyces cerevisiae
- RPS6A
- Saccharomyces cerevisiae
- RPS6B
- Schizosaccharomyces pombe
- rps6b
In other databases
- GenAge model organism genes
Studies (1)
Significant/Non-significant: 1/0
- Longevity Association
- Significant
- Population
- Dutch
- Study Design
- 1,018 SNPs within a 10-kb window around 40 mTOR signalling genes were studied for differences in variation between 417 unrelated nonagenarian participants and 476 younger controls
- Conclusions
- As a whole, there was a significant association of genetic variation in the mTOR pathway and familial longevity, though no individual gene was significant after correcting for multiple hypothesis testing
- Indentifier
- RPS6
- Reference