LongevityMap Gene
Gene details
- HGNC symbol
- RHOBTB3
- Aliases
- Common name
- Rho related BTB domain containing 3
- Description
- RHOBTB3 is a member of the evolutionarily conserved RHOBTB subfamily of Rho GTPases. For background information on RHOBTBs, see RHOBTB1 (MIM 607351).[supplied by OMIM, Apr 2004]
- Cytogenetic Location
- 5q15
- UCSC Genome Browser
- View 5q15 on the UCSC genome browser
- OMIM
- 607353
- Ensembl
- ENSG00000164292
- UniProt/Swiss-Prot
- RHBT3_HUMAN
- Entrez Gene
- 22836
- UniGene
- 445030
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
Studies (1)
Significant/Non-significant: 0/1
- Longevity Association
- Non-significant
- Population
- Italian
- Study Design
- Genome-wide association study on 410 long-living individuals (age range, 90–109 years) and 553 young control individuals (age range, 18–48 years) using 318,237 SNPs. An independent population with 116 long-lived individuals and 160 controls was used for replication purposes.
- Conclusions
- A total of 67 SNPs were identified with an indication of potentially being associated with longevity (p < 1 × 10−4), though 66 were not further validated
- Indentifier
- rs888808
- Reference