LongevityMap Gene
Gene details
- HGNC symbol
- RHEB
- Aliases
- RHEB2
- Common name
- Ras homolog enriched in brain
- Description
- This gene is a member of the small GTPase superfamily and encodes a lipid-anchored, cell membrane protein with five repeats of the RAS-related GTP-binding region. This protein is vital in regulation of growth and cell cycle progression due to its role in the insulin/TOR/S6K signaling pathway. The protein has GTPase activity and shuttles between a GDP-bound form and a GTP-bound form, and farnesylation of the protein is required for this activity. Three pseudogenes have been mapped, two on chromosome 10 and one on chromosome 22. [provided by RefSeq, Jul 2008]
- Cytogenetic Location
- 7q36.1
- UCSC Genome Browser
- View 7q36.1 on the UCSC genome browser
- OMIM
- 601293
- Ensembl
- ENSG00000106615
- UniProt/Swiss-Prot
- A0A090N900_HUMAN
- Entrez Gene
- 6009
- UniGene
- 283521
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
- Caenorhabditis elegans
- rheb-1
- Danio rerio
- rheb
- Drosophila melanogaster
- Rheb
- Mus musculus
- Rheb
- Rattus norvegicus
- Rheb
- Saccharomyces cerevisiae
- RHB1
- Schizosaccharomyces pombe
- rhb1
In other databases
- GenAge model organism genes
- A homolog of this gene for Caenorhabditis elegans is present as rheb-1
- GenDR gene manipulations
- A homolog of this gene for Caenorhabditis elegans is present as rheb-1
Studies (1)
Significant/Non-significant: 1/0
- Longevity Association
- Significant
- Population
- Dutch
- Study Design
- 1,018 SNPs within a 10-kb window around 40 mTOR signalling genes were studied for differences in variation between 417 unrelated nonagenarian participants and 476 younger controls
- Conclusions
- As a whole, there was a significant association of genetic variation in the mTOR pathway and familial longevity, though no individual gene was significant after correcting for multiple hypothesis testing
- Indentifier
- RHEB
- Reference