LongevityMap Gene
Gene details
- HGNC symbol
- RFC1
- Aliases
- A1; RFC; PO-GA; RECC1; MHCBFB; RFC140
- Common name
- replication factor C subunit 1
- Description
- This gene encodes the large subunit of replication factor C, a five subunit DNA polymerase accessory protein, which is a DNA-dependent ATPase required for eukaryotic DNA replication and repair. The large subunit acts as an activator of DNA polymerases, binds to the 3' end of primers, and promotes coordinated synthesis of both strands. It may also have a role in telomere stability. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Mar 2011]
- Cytogenetic Location
- 4p14
- UCSC Genome Browser
- View 4p14 on the UCSC genome browser
- OMIM
- 102579
- Ensembl
- ENSG00000035928
- UniProt/Swiss-Prot
- RFC1_HUMAN
- Entrez Gene
- 5981
- UniGene
- 507475
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
- Caenorhabditis elegans
- rfc-1
- Danio rerio
- rfc1
- Drosophila melanogaster
- Gnf1
- Mus musculus
- Rfc1
- Rattus norvegicus
- Rfc1
- Saccharomyces cerevisiae
- RFC1
- Schizosaccharomyces pombe
- rfc1
Studies (1)
Significant/Non-significant: 0/1
- Longevity Association
- Non-significant
- Population
- Danish
- Study Design
- 592 SNPs from 77 genes involved in nine sub-processes were analyzed in 1089 long-lived and 736 middle-aged Danes. Then, a replicated study was carried out in a German cohort.
- Conclusions
- The results did not remain significant after correction. The findings drawn from the Danish cohort were not replicated in German samples.
- Indentifier
- rs6829064
- Reference