LongevityMap Gene
Gene details
- HGNC symbol
- RARB
- Aliases
- HAP; RRB2; NR1B2; MCOPS12; RARbeta1
- Common name
- retinoic acid receptor beta
- Description
- This gene encodes retinoic acid receptor beta, a member of the thyroid-steroid hormone receptor superfamily of nuclear transcriptional regulators. This receptor localizes to the cytoplasm and to subnuclear compartments. It binds retinoic acid, the biologically active form of vitamin A which mediates cellular signalling in embryonic morphogenesis, cell growth and differentiation. It is thought that this protein limits growth of many cell types by regulating gene expression. The gene was first identified in a hepatocellular carcinoma where it flanks a hepatitis B virus integration site. Alternate promoter usage and differential splicing result in multiple transcript variants. [provided by RefSeq, Mar 2014]
- Cytogenetic Location
- 3p24.2
- UCSC Genome Browser
- View 3p24.2 on the UCSC genome browser
- OMIM
- 180220
- Ensembl
- ENSG00000077092
- UniProt/Swiss-Prot
- F1D8S6_HUMAN
- Entrez Gene
- 5915
- UniGene
- 543218
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
In other databases
- CellAge
- This gene is present as RARB
Studies (1)
Significant/Non-significant: 1/0
- Longevity Association
- Significant
- Population
- American (Caucasian)
- Study Design
- Genome-wide association study in 801 centenarians and 914 healthy controls
- Conclusions
- 281 SNPs were found to discriminate between cases and controls
- Indentifier
- rs922943
- Reference