LongevityMap Gene

Gene details

HGNC symbol: RAD51D
Aliases: TRAD; R51H3; BROVCA4; RAD51L3
Common name: RAD51 paralog D
Description: The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51, which are known to be involved in the homologous recombination and repair of DNA. This protein forms a complex with several other members of the RAD51 family, including RAD51L1, RAD51L2, and XRCC2. The protein complex formed with this protein has been shown to catalyze homologous pairing between single- and double-stranded DNA, and is thought to play a role in the early stage of recombinational repair of DNA. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the downstream ring finger and FYVE-like domain containing 1 (RFFL) gene. [provided by RefSeq, Jan 2011]
Cytogenetic Location: 17q12
UCSC Genome Browser: View 17q12 on the UCSC genome browser
OMIM: 602954
Ensembl: ENSG00000185379
UniProt/Swiss-Prot: RA51D_HUMAN
Entrez Gene: 5892
UniGene: 631757
1000 Genomes: 1000 Genomes

Homologs in model organisms

Caenorhabditis elegans: rad-51
Danio rerio: rad51d
Drosophila melanogaster: Rad51C
Mus musculus: Rad51d
Rattus norvegicus: Rad51d
Saccharomyces cerevisiae: RAD51

In other databases

GenAge model organism genes

A homolog of this gene for Saccharomyces cerevisiae is present as RAD51

CellAge gene expression

This gene is present as RAD51D

Studies (1)

Significant/Non-significant: 1/0

Longevity Association

Significant

Population

American (Caucasian)

Study Design

Genome-wide association study in 801 centenarians and 914 healthy controls

Conclusions

281 SNPs were found to discriminate between cases and controls

Indentifier

Reference