LongevityMap Gene
Gene details
- HGNC symbol
- PREX1
- Aliases
- P-REX1
- Common name
- phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1
- Description
- The protein encoded by this gene acts as a guanine nucleotide exchange factor for the RHO family of small GTP-binding proteins (RACs). It has been shown to bind to and activate RAC1 by exchanging bound GDP for free GTP. The encoded protein, which is found mainly in the cytoplasm, is activated by phosphatidylinositol-3,4,5-trisphosphate and the beta-gamma subunits of heterotrimeric G proteins. [provided by RefSeq, Jul 2008]
- Cytogenetic Location
- 20q13.13
- UCSC Genome Browser
- View 20q13.13 on the UCSC genome browser
- OMIM
- 606905
- Ensembl
- ENSG00000124126
- UniProt/Swiss-Prot
- PREX1_HUMAN
- Entrez Gene
- 57580
- UniGene
- 153310
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
Studies (1)
Significant/Non-significant: 1/0
- Longevity Association
- Significant
- Population
- American (Caucasian)
- Study Design
- Genome-wide association study in 801 centenarians and 914 healthy controls
- Conclusions
- 281 SNPs were found to discriminate between cases and controls
- Indentifier
- rs4596036
- Reference