LongevityMap Gene

Gene details

HGNC symbol: PON3
Aliases
Common name: paraoxonase 3
Description: This gene is a member of the paraoxonase family and lies in a cluster on chromosome 7 with the other two family members. The encoded protein is secreted into the bloodstream and associates with high-density lipoprotein (HDL). The protein also rapidly hydrolyzes lactones and can inhibit the oxidation of low-density lipoprotein (LDL), a function that is believed to slow the initiation and progression of atherosclerosis. Alternatively spliced variants which encode different protein isoforms have been described; however, only one has been fully characterized. [provided by RefSeq, Jul 2008]
Cytogenetic Location: 7q21.3
UCSC Genome Browser: View 7q21.3 on the UCSC genome browser
OMIM: 602720
Ensembl: ENSG00000105852
UniProt/Swiss-Prot: PON3_HUMAN
Entrez Gene: 5446
UniGene: 440967
1000 Genomes: 1000 Genomes

Homologs in model organisms

Caenorhabditis elegans: poml-2
Caenorhabditis elegans: poml-4
Caenorhabditis elegans: poml-3
Caenorhabditis elegans: mec-6
Danio rerio: pon3.2
Danio rerio: pon3.2
Danio rerio: pon2
Danio rerio: pon1
Mus musculus: Pon3
Rattus norvegicus: Pon3

Studies (1)

Significant/Non-significant: 0/1

Longevity Association

Non-significant

Population

Danish

Study Design

38 genes (311 SNPs) belonging to pro-antioxidant pathways were investigated for the association with physical and cognitive performances in a Cohort of 1089 Danish nonagenarians. For each gene analyzed in the pro-antioxidant pathway, the influence on longitudinal survival was tested.

Conclusions

No gene found associated with a functional phenotype showed a corresponding association with survival in the whole cohort. NDUFS1, TXNRD1, SOD2 and UCP3 were found significantly associated with lifespan in the female cohort. No association with survival was reported in males for genes belonging to the pro-oxidant pathway here analyzed.

Indentifier

rs17879277

Reference