LongevityMap Gene
Gene details
- HGNC symbol
- PKNOX2
- Aliases
- PREP2
- Common name
- PBX/knotted 1 homeobox 2
- Description
- Homeodomain proteins are sequence-specific transcription factors that share a highly conserved DNA-binding domain and play fundamental roles in cell proliferation, differentiation, and death. PKNOX2 belongs to the TALE (3-amino acid loop extension) class of homeodomain proteins characterized by a 3-amino acid extension between alpha helices 1 and 2 within the homeodomain (Imoto et al., 2001 [PubMed 11549286]).[supplied by OMIM, Oct 2009]
- Cytogenetic Location
- 11q24.2
- UCSC Genome Browser
- View 11q24.2 on the UCSC genome browser
- OMIM
- 613066
- Ensembl
- ENSG00000165495
- UniProt/Swiss-Prot
- B7ZAF3_HUMAN
- Entrez Gene
- 63876
- UniGene
- 278564
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
- Danio rerio
- pknox2
- Mus musculus
- Pknox2
- Rattus norvegicus
- Pknox2
- Saccharomyces cerevisiae
- CUP9
- Saccharomyces cerevisiae
- TOS8
In other databases
- GenAge model organism genes
Studies (1)
Significant/Non-significant: 1/0
- Longevity Association
- Significant
- Population
- American (Caucasian)
- Study Design
- Genome-wide association study in 801 centenarians and 914 healthy controls
- Conclusions
- 281 SNPs were found to discriminate between cases and controls
- Indentifier
- rs590211
- Reference