LongevityMap Gene

Gene details

HGNC symbol: PGPEP1
Aliases: PGI; PGP; Pcp; PGPI; PAP-I; PGP-I
Common name: pyroglutamyl-peptidase I
Description: The gene encodes a cysteine protease and member of the peptidase C15 family of proteins. The encoded protein cleaves amino terminal pyroglutamate residues from protein substrates including thyrotropin-releasing hormone and other neuropeptides. Expression of this gene may be downregulated in colorectal cancer, while activity of the encoded protein may be negatively correlated with cancer progression in colorectal cancer patients. Activity of the encoded protease may also be altered in other disease states including in liver cirrhosis, which is associated with reduced protease activity, and in necrozoospermia, which is associated with elevated protease activity. [provided by RefSeq, Jul 2016]
Cytogenetic Location: 19p13.11
UCSC Genome Browser: View 19p13.11 on the UCSC genome browser
OMIM: 610694
Ensembl: ENSG00000130517
UniProt/Swiss-Prot: PGPI_HUMAN
Entrez Gene: 54858
UniGene: 131776
1000 Genomes: 1000 Genomes

Significant/Non-significant: 1/0

Longevity Association

Significant

Population

American (Caucasian)

Study Design

Genome-wide association study in 801 centenarians and 914 healthy controls

Conclusions

281 SNPs were found to discriminate between cases and controls

Indentifier

rs11086106

Reference